In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 150726-89-9, name is Dimethyl 2-(2-methoxyphenoxy)malonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 150726-89-9
Preparation 2 5-(2-Methoxyphenoxy)-2-(3-pyridazinyl)-4,6-pyrimidinediol Dimethyl 2-(2-methoxyphenoxy)malonate (3.05 g, 12.6 mmol) (Ref. Canadian Patent Application No. CA2071193A, 1992) in methanol (15 ml) was added over 5 minutes to a stirred, 25% w/v solution of sodium methoxide in methanol (8.58 ml, 37.8 mmol of sodium methoxide) at room temperature. The resulting mixture was stirred for 10 minutes and then a solution of 3-pyridazinecarboximidamide hydrochloride (2.0 g, 12.6 mmol) in methanol (15 ml) was added dropwise over 5 minutes and the resulting mixture was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and then diluted with water (100 ml). The aqueous solution was acidified to pH 4 with sulfuric acid (20%), resulting in the formation of the title compound as a purple solid, which was isolated by filtration (1.4 g). 1H-NMR (300 MHz, DMSO-d6): 3.83 (s, 3H), 6.68 (d, 1H), 6.78 (t, 1H), 6.93 (t,1H), 7.03 (d,1H), 7.94 (dd,1H), 8.34 (d,1H), 9.43 (d,1H) ppm. HRMS (+ve ion) found: m/z 313.0929 (MH+). C15H12N4O4+H requires m/z 313.0932
The synthetic route of 150726-89-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Banks, Bernard Joseph; Chubb, Anthony Logan; Critcher, Douglas James; Eshelby, James John; Schulz, Darren John; US2002/61889; (2002); A1;,
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