Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 653-92-9, name is Methyl 2-bromo-4-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Methyl 2-bromo-4-fluorobenzoate
To a solution of methyl 2-bromo-4-fluorobenzoate (1.2 g, 5.15 mmol) in DMF (5 mL) was added cyanocopper (0.92 g, 10.3 mmol) under N2. The reaction was stirred at 120 C for 1.5 h under N2. Then, the reaction was cooled to room temperature.10% NaCN (10 mL) was added to the reaction. The mixture was extracted with DCM (3 x 30 mL). The layers were separated and the organic phase was washed with saturated aqueous NaCl (3 x 50 mL) .The combined organic layers were dried over Na2SO4. After filtration, 850 mg of product was obtained as a white solid.
According to the analysis of related databases, 653-92-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; HEFFERNAN, Michele L.R.; HARDY, Larry Wendell; BROWN, Scott P.; HERMAN, Lee W.; (180 pag.)WO2018/26371; (2018); A1;,
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