Application of Methyl 2-(4-bromophenyl)acetate

Reference of 41841-16-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows.

Reference of 41841-16-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of the methyl 2-bromophenylacetate (0.86 ml; 5.31 mmol) in dichloromethane (10.2 ml, 159 mmol) are added N- bromosuccinimide (1 .04 g, 5.84 mmol) and azobisisobutyronitrile (43.6 mg, 0.27 mmol) at room temperature and the mixture is stirred at 100 C for 16 h under argon atmosphere. The reaction mixture is cooled down to room temperature. The mixture is diluted with diethyl ether and filtered. The filtrate is evaporated to dryness. The oily residue containing solid succinimid is diluted with heptane and filtered again. The solvent is removed to afford methyl 2-bromo-2-(4-bromophenyl)acetate (1 .38 g, 4.56 mmol, 86 % of theory).

The chemical industry reduces the impact on the environment during synthesis Methyl 2-(4-bromophenyl)acetate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK PATENT GMBH; SCHRAUB, Martin; DOBELMANN-MARA, Lars; RIEDMUELLER, Stefan; (326 pag.)WO2018/149852; (2018); A1;,
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