Adding a certain compound to certain chemical reactions, such as: 27829-72-7, name is Ethyl E-hex-2-enoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27829-72-7, SDS of cas: 27829-72-7
Adding a certain compound to certain chemical reactions, such as: 27829-72-7, name is Ethyl E-hex-2-enoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27829-72-7, SDS of cas: 27829-72-7
Example D: (S)-3-Amino-hexanoic acid ethyl ester To a solution of (S)-(-)-N-benzyl-alpha-methyl-benzylamine (50 mL, 239 mmol) in THF (150 mL) at 00C is added nBuLi (2.5 M in THF) (100 mL, 250 mmol) under nitrogen atmosphere. The solution is cooled to -78°C and ethyl trans-2-hexenoate (16.6 g, 117 mmol) is added. The solution is stirred for 1 hour and saturated NH4Cl solution is added. The solution is warmed to room temperature and is extracted with EtOAc. The combined organic layer is dried with MgSO4 and is filtered. The filtrate is concentrated and the residue is purified by flash chromatography with 5percent EtOAc in Hexane as the eluent to afford the (S)-3-[Benzyl-((S)-l- phenyl-ethyl)-amino]-hexanoic acid ethyl ester (20.8 g, 50percent) as a colorless oil.
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Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2009/23655; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics