Application of 5445-17-0,Some common heterocyclic compound, 5445-17-0, name is Methyl 2-bromopropanoate, molecular formula is C4H7BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-bromo-propanoic acid, methyl ester (0.03 mol) was added to a solution of potassium fluoride (0.075 mol) in DMF (25ml). The mixture was stirred at room temperature for 15 minutes. 2-amino-5-nitro- phenol (0.03 mol) was added. The mixture was stirred at 600C for 6 hours, poured out into ice water (150ml), filtered, washed with water and dried, yielding 7g of intermediate 16.
The synthetic route of 5445-17-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2009/37343; (2009); A1;,
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