Application of 35180-01-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35180-01-9, name is Chloromethyl isopropyl carbonate, This compound has unique chemical properties. The synthetic route is as follows.
Compound 14 (50 mg, 0.106 mmol) was dissolved in DMF (1 mL) and chloromethyl propan- 2-yl carbonate (24 mg, 0.158 mmol) and K2C03 (22 mg, 0.158 mmol) were added. The mixture was stirred at 50C for 30 min. The reaction mixture was diluted with EtOAc and washed with water. The combined organic phases were dried over MgS04, filtered, and evaporated in vacuo. The crude was purified by flash chromatography on silica gel using a gradient of EtOAc in cHex to yield the desired product 121 (58 mg, 93%) as a white powder. 1H NMR (400MHz, DMSO-d6) delta 7.70 (dd, 1 H), 7.59-7.52 (m, 1 H), 7.46-7.40 (m, 1 H), 7.01 – 6.90 (m, 2H), 6.87-6.75 (m, 1 H), 6.31 (s, 1 H), 5.82-5.64 (m, 2H), 5.52-5.42 (m, 1 H), 4.84- 4.73 (m, 1 H), 4.20-3.50 (m, 2H), 3.28-3.02 (m, 2H), 2.72-2.53 (m, 1 H), 2.02-1.88 (m, 1 H), 1 .82-1.36 (m, 6H), 1 .28-1.20 (m, 6H). MS (ES) C29H29CIFN09 requires: 589/591 , found: 590/592 (M+H)+, 99%
The chemical industry reduces the impact on the environment during synthesis Chloromethyl isopropyl carbonate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; LEAD DISCOVERY CENTER GMBH; MAX PLANCK GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E. V.; SOTIO A.S.; DI LUCREZIA, Raffaella; BERGBREDE, Tim; NUSSBAUMER, Peter; KOCH, Uwe; KLEBL, Bert; CHOIDAS, Axel; UNGER, Anke; LARSSON, Nils-Goeran; FALKENBERG-GUSTAFSSON, Maria; GUSTAFSSON, Claes M.; (157 pag.)WO2019/57821; (2019); A1;,
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