Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 179022-43-6, name is Methyl 8-azabicyclo[3.2.1]octane-3-carboxylate hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Methyl 8-azabicyclo[3.2.1]octane-3-carboxylate hydrochloride
A mixture of (3-bromo-lH-pyrazolo[4,3-b]pyridin-l-yl)(2-chloro-6-(trifluoromethyl) phenyl)methanone (B-1) (200mg, 0.50mmol), 3-(methoxycarbonyl)-8-azonia- bicyclo[3.2.1]octane chloride 2 (0.15 g, 0.75 mmol) and Cs2C03 (0.65g, 2.0mmol) were suspended in DMF (5mL). The reaction mixture was heated at 150C in a microwave reactor for 5h. The result mixture was diluted with H20 (50mL). 2M HCl solution was added to adjust the pH~3 and the aqueous layer was extracted with ethyl acetate (3x20mL). The combined organic layers were washed with brine (20mL), dried over anhydrous Na2S04 and concentrated to get the crude product B-2 as yellow oil. LCMS (ESI) calc’d for C23H20ClF3N4O3 [M+H]+: 493, found: 493
According to the analysis of related databases, 179022-43-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BARR, Kenneth Jay; MACLEAN, John; ZHANG, Hongjun; BERESIS, Richard Thomas; WO2014/26330; (2014); A1;,
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