Synthetic Route of 4934-99-0, A common heterocyclic compound, 4934-99-0, name is Methyl 3-hydroxycyclobutanecarboxylate, molecular formula is C6H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
At -10 , to 3-hydroxy-cyclobutane carboxylate (3.2g, 24.61mmol, 1eq.) In DCM (100mL) was added triethylamine(10.25mL, 73.83mmol, 3eq.) And methanesulfonyl chloride (2.29mL, 29.54mmol, 1.2eq.), The reaction was stirred at -10 3h. again60mL saturated ammonium chloride solution was added, the separated organic phase was washed with saturated sodium chloride solution (50mL x 2), dried over anhydrous sodium sulfate, and thenAfter concentration under reduced pressure, the residue was concentrated by silica gel column chromatography (eluent: PE / EtOAc (V / V) = 5/1) to give the title compound as a colorless oil (4.9 g of,95.7%).
The synthetic route of 4934-99-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; East Sunshine Pharmaceutical Co., Ltd. of Guangdong; Ren, Qingyun; Luo, Huichao; Tang, Changhua; Zhang, Jiancun; Zhang, Yingjun; (30 pag.)CN104447583; (2016); B;,
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