Adding a certain compound to certain chemical reactions, such as: 17205-02-6, name is Ethyl 3-hydroxycyclobutanecarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17205-02-6, Quality Control of Ethyl 3-hydroxycyclobutanecarboxylate
To a diethyl ether solution (30 mL) containing methyl magnesium bromide (7.63 mL of a 3.0 M diethyl ether solution) was added a diethyl ether solution (5 mL) containing ethyl 3- hydroxycyclobutane carboxylate (2.05 g, 6.94 mmol), dropwise. After two hours, the reaction was carefully quenched with 3 M aqueous hydrochloric acid. Magnesium sulfate was added until the evolution of gas stopped. The solution was filtered, and the solvent removed in vacuo yielding a viscous oil which was purified by silica gel chromatography, eluting with ethyl acetate:hexanes (1 :1 to 1 :0) to give 3-(2-hydroxypropan-2-yl)cyclobutanol (419 mg, 3.22 mmol, 46%). 1H NMR (CDCI3) delta 1 .13 (s, 6 H), 1 .74-1 .86 (m, 4 H), 2.23-2.39 (m, 2 H), 2.66 (br s, 1 H), 4.03-4.09 (m, 1 H).
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Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DEATON, Dave Norman; SHEARER, Barry George; YOUNGMAN, Mark Andrew; (214 pag.)WO2018/229629; (2018); A1;,
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