Application of 139102-34-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 139102-34-4, name is Methyl 4-bromo-2-methoxybenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Under the protection of nitrogen,Compound 49E (150 mg, 0.66 mmol),Methyl 4-bromo-2-methoxybenzoate (168 mg, 0.69 mmol),Palladium acetate (15 mg, 0.066 mmol), BINAP (42 mg, 0.066 mmol),Barium carbonate (324mg, 0.99mmol)The 1,4-dioxane solution was heated to 110 C for 4 hours and then lowered to room temperature.The reaction was quenched with EtOAc (EtOAc)EtOAc.The compound was quenched under reduced pressure to give compound 49F (90 mg, 35% yield)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-bromo-2-methoxybenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Chen Huanming; Liang Bo; Cao Wenjie; Zhang Guiping; Zhao Zhongqiang; Jiang Zhaojian; Zuo Gaolei; Xu Wanmei; Gong Hongju; Zhang Peng; Wang Jianghuai; Li Qingsong; Gao Chunhua; (79 pag.)CN104045552; (2019); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics