Adding a certain compound to certain chemical reactions, such as: 4630-80-2, name is Methyl cyclopentanecarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4630-80-2, category: esters-buliding-blocks
General procedure: Into an oven-dried reaction vial flushed with N2 were taken esters 8 (0.60 mmol) and anhydrous toluene (3.0 mL). The reaction vial was cooled to -78C and LDA (2M in THF, 0.36 mL) was added dropwise with stirring. After 1h at -78C, sulfinylimine 7 (0.5 mmol) dissolved in anhydrous toluene (2.0 mL) was added dropwise. Stirring was continued for 2 h with the temperature gradual rising to room temperature, then the reaction was quenched with saturated H2O (3.0 mL). The organic layer was taken and the aqueous layer was extracted with EtOAc (2×20 mL). The combined organic layers were dried with anhydrous Na2SO4, filtered and the solvent was removed to give the crude product 9, which was purified by column chromatography (hexane/EtOAc, 4:1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl cyclopentanecarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Dai, Yanling; Xie, Chen; Mei, Haibo; Han, Jianlin; Soloshonok, Vadim A.; Pan, Yi; Tetrahedron; vol. 71; 51; (2015); p. 9550 – 9556;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics