Synthetic Route of 6942-37-6,Some common heterocyclic compound, 6942-37-6, name is Methyl 5-amino-2-bromobenzoate, molecular formula is C8H8BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Into a solution of the aniline compound (1O g = 43.48 mmol) and triethylamine (TEA. 11.53 ml. = 86.96 mmol) in 100 ml. of toluene, 1 ,4-dibromobutane (10.39 ml. = 86.96 mmol) was added. The reaction mixture was heated to 100 0C for 5 h. The resulting reaction mixture was concentrated, re-diluted with ethyl acetate, washed with saturated NaHCOs aqueous solution and NaCI aqueous solution, dried over MgSO4, then filtered and concentrated. The residue was chromatographed over a 120 g silica column, eluting with 20 % ethyl acetate in hexane to provide 7.1 g of the product 2-(4-pyrrolidin-1-yl-2-methylhydroxy- phenyl)-4,5,6-tetrahydro-thiazolo[4,5-c]pyridin-7-ol as a light yellow solid, MS: m/z 284.1 , 286.1 (M+H).
The synthetic route of 6942-37-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; WYETH; WO2009/120849; (2009); A1;,
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