Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 685-88-1, name is Diethyl fluoromalonate, A new synthetic method of this compound is introduced below., Application In Synthesis of Diethyl fluoromalonate
Sodium metal (9.68 g, 421 mmol) was cut in small pieces and added to dry EtOH (300 mL) in portions. After all the sodium was dissolved, morpholine-4-carboxamidine sulfate (30 g, 168 mmol) and diethyl fluoromalonate (30 g, 168 mmol) were added to the mixture at 10 C. The resulting white suspension was stirred at 20 C. for 10 min and then heated under reflux for 12 h. The resulting purple suspension was concentrated under reduced pressure and water (150 mL) was added. The solution was treated with 6N HCl (60 mL) to obtain pH-4 at 10 C. The resulting yellow precipitate was collected by filtration, washed with water (40 mL*2) and the yellow filter cake was dried under an infrared lamp for 12 h to give 34 g (94%) of the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 3.65-3.57 (m, 4H) 3.53-3.46 (m, 4H); m/z (APCI-) for C8H10FN3O3 214.1 (M-H)-.
The synthetic route of 685-88-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; Chen, Ping; CHENG, Hengmiao; Gallego, Gary Michael; Jalaie, Mehran; Kath, John Charles; Orr, Suvi Tuula Marjukka; PAIRISH, Mason Alan; (100 pag.)US2017/15689; (2017); A1;,
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