Some common heterocyclic compound, 5445-17-0, name is Methyl 2-bromopropanoate, molecular formula is C4H7BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 2-bromopropanoate
General procedure: To a solution of appropriate amount of 3-(arylimino)-2,3-dihydro-1H-isoindol-1-one 15 (0.75 mmol) in 10 cm3 dryacetone methyl 2-bromoalkanoate (1.12 mmol), 0.186 gpotassium iodide (1.12 mmol), and 0.207 g anhydrouspotassium carbonate (1.5 mmol) were added. The obtainedmixture was stirred at room temperature until the TLCshowed the absence of starting isoindolone 15(* 2-3 days). After that inorganic salts were filtered offand washed with 5 cm3 acetone. The filtrate was concentratedunder reduced pressure and the crude product waspurified by column chromatography (EtOAc/petroleumether 1:1) to afford the desired compound 16.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5445-17-0, its application will become more common.
Reference:
Article; Tkachuk, Volodymyr A.; Hordiyenko, Olga V.; Omelchenko, Irina V.; Medviediev, Volodomir V.; Arrault, Axelle; Monatshefte fur Chemie; vol. 149; 12; (2018); p. 2293 – 2309;,
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