Analyzing the synthesis route of 27829-72-7

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27829-72-7, name is Ethyl E-hex-2-enoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Ethyl E-hex-2-enoate

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27829-72-7, name is Ethyl E-hex-2-enoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Ethyl E-hex-2-enoate

To a stirred solution of l-l,2-benzisoxazol-3-ylmethyl-l,3-dihydro-benzimidazol-2-one (lOOmg, 0.38mmol) in DMF (5ml) was added ethyl trans-2-hexenoate (80mg, 0.57mmol) followed by benzyltrimethylammonium hydroxide (Triton B, 40 wtpercent in MeOH, 17.OuI). The resulting mixture was warmed to 6O0C for 12h and cooled to ambient temperature. The reaction was diluted with NH4Cl (sat.) and the product was extracted into ethyl acetate (2x). The combined organics were dried (MgSO4), filtered and concentrated to give the crude product which was purified via column chromatography (silica gel, 5percent EtOAc/dichloromethane). The product- containing fractions were combined and concentrated to give 70mg (46percent) of the desired product.

The synthetic route of 27829-72-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/147697; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics