Adding a certain compound to certain chemical reactions, such as: 154825-97-5, name is Methyl 2-(4-bromophenyl)-2,2-dimethylacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 154825-97-5, Application In Synthesis of Methyl 2-(4-bromophenyl)-2,2-dimethylacetate
methyl 3-bromophenyltert-butanoate (formula II) (257g), ethenyl benzyl ether (formula V) (140g), potassium carbonate (138g), and 1,4-dioxane (2L), Replaced 3 times with nitrogen, added tetratriphenylphosphine palladium (3g), and reacted at 100 C for 12h. The reaction was monitored by TLC for completion. The complete reaction system was reduced to room temperature, filtered, and concentrated to remove 1,4-dioxane. Water (1 L) ethyl acetate (1 L) was added, and the layers were separated. The organic phase was dried over anhydrous sodium sulfate and concentrated to dryness to give methyl 4-(2-benzyloxyethenyl)phenyltert-butanoate (formula III) (300 g), yield: 96.7%, purity: 98%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-(4-bromophenyl)-2,2-dimethylacetate, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Tiancizhong Business Pharmaceutical Co., Ltd.; Chi Wangzhou; Li Hanpu; Ma Xilai; Li Yonggang; Sha Fei; (8 pag.)CN110734375; (2020); A;,
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