Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6290-49-9, name is Methyl 2-methoxyacetate, A new synthetic method of this compound is introduced below., COA of Formula: C4H8O3
General procedure: To a distilled benzene solu-tion (50 mL) of methyl 2-methoxyacetate (5.2 g, 50 mmol) wereadded a magnetic stirring bar and N-bromosuccinimide (8.9 g,50 mmol), and the mixture was stirred at room temperature for 1 hunder irradiation of a sunlight lamp. The reaction mixture was l-tered, and then evaporated under reduced pressure. The residuewas dissolved in THF (50 mL) containing sec-amine (60 mmol) andtriethylamine (6.1 g, 60 mmol), and the mixture was stirred for 2 hat room temperature. The mixture was directly ltered withouta common workup and was evaporated under reduced pressure.The ltrate was distilled (a Kugelrohr distillation) to give the N,O-acetal 2. 4.1.1.4. Methyl 2-(diallylamino)-2-methoxyacetate16d(2d). 75%yield (7.47 g); colorless oil;1H NMR (300 MHz, CDCl3) d 3.26e3.36(m, 7H), 3.77 (s, 3H), 4.46 (s, 1H), 5.13e5.24 (m, 4H), 5.80 (m, 2H);13C NMR (75 MHz, CDCl3) d 51.8, 52.1, 55.5, 89.7, 117.5, 135.7, 169.8;MS (ESI): m/z 222 [MNa]; HRMS (ESI): Calcd for C10H17NNaO3:222.1106, found: 222.1095.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Sakai, Norio; Hori, Hiroaki; Yoshida, Yoshihiro; Konakahara, Takeo; Ogiwara, Yohei; Tetrahedron; vol. 71; 29; (2015); p. 4722 – 4729;,
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