In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40637-56-7, name is Dimethyl 2-allylmalonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Dimethyl 2-allylmalonate
A typical procedure for the iodine(III) reagent-induced anti-Markovnikov hydroazidation of unactivated alkenes: to asolution of 4-phenyl-1-butene (1a) (0.030 mL, 0.2 mmol)and ABX-N3 (11.6 mg, 0.04 mmol) in dichloromethane(DCM) (0.2 mL), TMSN3 (0.052 mL, 0.4 mmol) and HOAc(0.024 mL, 0.4 mmol) were added under an argon atmosphereat room temperature. The reaction mixture was thenstirred for 4 h and monitored by thin layer chromatography(TLC) until 1a was completely consumed. After that, theaqueous of NaOH was added to quench extra HN3 [18], andthe mixture was extracted by Et2O for two times. The organiclayer was dried over MgSO4, filtered and concentrated undervacuum. The residue was purified by flash column chromatography(petroleum ether/ethyl acetate, 20:1 to 10:1) togive product 2a in 83% yield.
The synthetic route of 40637-56-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Li, Xiaonan; Chen, Pinhong; Liu, Guosheng; Science China Chemistry; vol. 62; 11; (2019); p. 1537 – 1541;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics