Adding a certain compound to certain chemical reactions, such as: 51760-21-5, name is Dimethyl 5-bromoisophthalate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51760-21-5, Application In Synthesis of Dimethyl 5-bromoisophthalate
Step a) 5-Bromo-isophthalic acid monomethyl ester (Acid-7a); 1 M NaOH (1.19 ml, 1.91 mmol) was added to a solution of dimethyl 5-bromoisophthalate (522 mg, 1.91 mmol) in THF (10 ml) and MeOH (10 ml). The mixture was stirred at ambient temperature overnight. Most of solvents were evaporated, 2 M HCl (6 ml) was added and aqueous phase was extracted with EtOAc. The combined organic layers were dried (MgSO4) and evaporated, which gave the title compound (484 mg, 98%) as a white solid.
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Reference:
Patent; MEDIVIR AB; LUNDBERG, Stina; AYESA, Susana; BELDA, Oscar; DORANGE, Ismet; ERSMARK, Karolina; HAMMER, Kristin; JOHANSSON, Per-Ola; LINDSTROeM, Stefan; ROSENQUIST, Asa; SAMUELSSON, Bertil; BAeCK, Marcus; KVARNSTROeM, Ingemar; WANGSELL, Fredrik; BJOeRKLUND, Katarina; WO2010/42030; (2010); A1;,
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