Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4606-07-9, name is Ethyl cyclopropanecarboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl cyclopropanecarboxylate
General procedure: To a three-necked, 50 mL flaskequipped with a magnetic stirring bar, 15 mL of THF, 2.5 mmol of ester (1 equiv), 0.375 mmol of CuO (15% equiv), 7.5 mmol of aryl halides and magnesium chips (3 equiv) or 15 mmol of alkyl bromides and magnesium chips (6 equiv) were added. The reaction mixture was heated at 65 C for 4 h. The progress of the reaction was monitored by TLC. Then, the reaction was quenched by saturated aqueous NH4Cl (5 mL), extracted with AcOEt (10 mL × 3), dried over sodium sulfate, filtered, and evaporated to give the raw product. Pure product could be obtained by TLC with petroleum /AcOEt = 5/1 as eluent.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Gao, Fei; Deng, Xiang-Jun; Tang, Yu; Tang, Jin-Peng; Yang, Jun; Zhang, Yuan-Ming; Tetrahedron Letters; vol. 55; 4; (2014); p. 880 – 883;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics