In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 121-98-2 as follows. Recommanded Product: Methyl 4-methoxybenzoate
To a cooled (-20 C) solution of 4-methoxybenzoic acid methyl ester 11 (3.00 g, 18.1 mmol) in MeCN (30 mL) was added HBF4·Et2O (3.22 mL, 19.9 mmol) and then slowly added NBS (3.54 g, 19.9 mmol) under less than -10 C. After the addition, the cooling bath was removed and the reaction mixture was allowed to warm up to room temperature, and stirred for 23 h. Saturated NaHSO3 solution was then added, and the reaction mixture was extracted with EtOAc. The combined organic layers were washed with saturated NH4Cl solution and brine, dried over Na2SO4, and then concentrated in vacuo. Purification by silica gel column chromatography (hexane/EtOAc = 5/1) gave 12 (4.35 g, 17.7 mmol, 98%) as a colorless powder;
According to the analysis of related databases, 121-98-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ogura, Tetsuhiro; Usuki, Toyonobu; Tetrahedron; vol. 69; 13; (2013); p. 2807 – 2815;,
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