Electric Literature of 28868-76-0,Some common heterocyclic compound, 28868-76-0, name is Dimethyl 2-chloromalonate, molecular formula is C5H7ClO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
c) 18.2 g of 2-chloro-5-methoxyphenol were dissolved in 150ml of dry methanol. 9.3 g of MeONa followed by 25 g of dimethyl chloromalonate were added. The reaction mixture was stirred at 50 C. for 2 hours. After distillation of the solvent the residue was partitioned between toluene and H2 O in a separating funnel and washed neutral. After crystallization in ethanol there was obtained dimethyl (2-chloro-5-methoxy)phenoxy-malonate, white crystals with m.p. 68-69 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Dimethyl 2-chloromalonate, its application will become more common.
Reference:
Patent; Hoffmann-La Roche Inc.; US5541186; (1996); A;,
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