Related Products of 106896-49-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 106896-49-5, name is Methyl 4-amino-3-bromobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: An over-dried vial equipped with stir bar was charged with Pd(OAc)2 (0.0055 g, 0.0245mmol, 0.10 equiv.), dppb (0.020 g, 0.0489 mmol, 0.2 equiv.) and K2CO3 (0.15 g, 0.98 mmol, 4.0equiv.). Freshly distilled toluene was introduced into the vial via syringe and the contents were allowed to stir. A second over-dried vial equipped with a stir bar was charged with cyclopropanol (0.05 g, 0.245 mmol, 1.0 equiv.) and 2-bromoaniline (0.084 g, 0.489 mmol, 2.0equiv.). Freshly distilled toluene was introduced into the vial via syringe and contents allowed to stir. The solution of substrates was added to the solution containing the palladium catalyst. The reaction vial was purged with argon, capped with a rubber septum and heated to 110 C for 24hrs. Upon completion, the reaction mixture was filtered through a pad of celite using EtOAc, and concentrated in vacuo. The crude product was purified by flash column chromatography, eluting with the indicated solvent mixture to afford the desired quinoline product. Purification by flash column chromatography using 20% EtOAc in hexanes provided the desired quinoline as a pale yellow oil (0.051 g, 0.19 mmol) in 76% yield
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-3-bromobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Nikolaev, Andrei; Nithiy, Nisha; Orellana, Arturo; Synlett; vol. 25; 16; (2014); p. 2301 – 2305;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics