Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 383-62-0, name is Ethyl 2-chloro-2,2-difluoroacetate, A new synthetic method of this compound is introduced below., Recommanded Product: 383-62-0
A mixture of A (5.0 g, 32.9 mmol) and ethyl 2-chloro-2,2-difluoroacetate (5.7 g, 36.0 mmol), potassium carbonate (4.5 g. 32.9 mmol) in dry DMF (90 mL) were stirred at 600C for 6 hours under an N2 atmosphere. Then the reaction was stirred at rt. for another 60 hours. Ether (200 mL) was added to the mixture and the layers separated. The organic phase was washed with water (100 mL* 3), dried over Na2SO^, evaporated and purified on silica chromatography with eluent (EtOAc: PE = 1: 12) to afford B 2.3 g.
The synthetic route of 383-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CVI PHARMACEUTICALS LIMITED; LIU, Haiyan; LI, Gaoping; WANG, Junbo; LIU, Jingwen; WO2010/75469; (2010); A1;,
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