Adding a certain compound to certain chemical reactions, such as: 25597-16-4, name is Ethyl 4,4,4-trifluorocrotonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25597-16-4, category: esters-buliding-blocks
The resulting product (2.02g, 0.013mol) from step 4, ethyl 4,4,4-trifluorocrotonate (4.30g, 0.026mol) and anhydrous potassium carbonate (1.76g, 0.013mol) were dissolved in DMF (70mL), and then the system was stirred for 6hrs at 80C. At the end of reaction, the reaction system was cooled to room temperature, added with water and then extracted with ethyl acetate, and the organic phase was dried and evaporated in vacuum to obtain 2.35g of the product (60.1 %) by column chromatography. 1HNMR(400MHz, d6-DMSO), deltappm 7.84(s,1H), 7.13(s,1H), 7.09(s,1H), 5.94(m,1H), 4.25(dd,1 H), 1.27(t,3H)
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Reference:
Patent; Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences; ZHANG, Yanmei; TALLEY, John Jeffrey; OBUKOWICZ, Mark G.; TU, Zhengchao; TORTORELLA, Micky; WANG, Yican; LIU, Jianqi; CHEN, Yan; LIU, Xiaorong; LU, Xin; EP2845854; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics