Application of 24812-89-3, These common heterocyclic compound, 24812-89-3, name is Methyl 3-amino-2,4-dimethylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Scheme 23. step A. To a solution of 2-chloroquinoline-4-carboxylic acid (0.40 g,0.0019 mol) in CH2Ch (8 mL) at 0C are added methyl3-amino-2,4-dimethylbenzoate(0.31 g, 0. 0017 mol, see preparation 10) and triethylamine (0.80 ml, 0.0058 mol). After stirring the reaction mixture for 10 minutes, 1-propanephosphonic acid cyclic anhydride(50% solution in ethyl acetate, 2.45 ml, 0.0038 mol) is added via syringe and stirred at room temperature. After 16 hours, the reaction is diluted with water and extracted twicewith dichloromethane. The organic layers are combined and dried over magnesiumsulfate, filtered, and concentrated under reduced pressure. The resulting residue istriturated with 20% diethyl ether in pentane and filtered to give the title compound as an off-white solid (0.55 g, 77 %). Mass spectrum (m/z): 369.1 (M+1).
Statistics shows that Methyl 3-amino-2,4-dimethylbenzoate is playing an increasingly important role. we look forward to future research findings about 24812-89-3.
Reference:
Patent; ELI LILLY AND COMPANY; BLANCO-PILLADO, Maria-Jesus; VETMAN, Tatiana Natali; FISHER, Matthew Joseph; KUKLISH, Steven Lee; WO2014/4230; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics