Synthetic Route of 58656-98-7, A common heterocyclic compound, 58656-98-7, name is tert-Butyl 4-fluorobenzoate, molecular formula is C11H13FO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
816 g of the intermediate 2 was dissolved in 2500 g of o-dichlorobenzene, 900 g of aluminum trichloride was added, andthe o-dichlorobenzene solution of the intermediate 3 of the previous step was added dropwise to the reaction systemat 10-15 C. After the completion of the dropwise addition, thereaction was carried out at 10-15 C for about 3 hours.After the completion of the reaction, 2500 g of a 5.0% aqueous hydrochloric acid solution was added to the system, and the mixture was stirred for 10 minutes, allowed to stand for separation, and the organic phase was retained, and thesolvent was distilled off under reduced pressure at 100-120 C. O-dichlorobenzene was added to 2000 ethanol, heated to 75 C to dissolve, cooled to 0-5 C forcrystallization, and the filter cake was dried at 60 C to obtain 1248 g of intermediate 4.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Jiangsu Baozhongbaoda Pharmaceutical Co., Ltd.; Chen Rong; Zhao Haihua; Wang Lin; (8 pag.)CN109535081; (2019); A;,
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