Application of 69812-51-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 69812-51-7 as follows.
General procedure: To a solution of compound 7 (400mg, 1.0 eq) in CH2Cl2 or MeCN (30mL), the substituted benzenesulfonyl chloride (1.2 eq), K2CO3 (3.5 eq) were added and stirred at room temperature overnight. After reaction completed, the solvent was removed under reduced pressure and the residue was dissolved with ethyl acetate, washed by brine, dried, filtered and concentrated. The residue was purified by flash column chromatography on silica gel with CH2Cl2/CH3OH as the eluents and then acidized with 2N HCl/Et2O (1mL) to give the title compounds (8a-h).
According to the analysis of related databases, 69812-51-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Cheng, Xin-Yue; Li, Yu-Huan; Tang, Sheng; Zhang, Xin; Wang, Yan-Xiang; Wang, Sheng-Gang; Jiang, Jian-Dong; Li, Ying-Hong; Song, Dan-Qing; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 133 – 142;,
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