Application of 23786-14-3,Some common heterocyclic compound, 23786-14-3, name is Methyl 4-methoxyphenylacetate, molecular formula is C10H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 6a: Methyl bromo(4 tate; To a mixture of methyl 4-methoxyphenylacetate (20 g, 0.11 mol) and NBS (0.11 mol) in CCI4 (0.2 I) were added 3 drops of 48% HBr and this mixture was heated to reflux for 8 h. The cooled solution was filtered through a pad of silica gel and the filtrate was evaporated in vacuo to give 29 g of the title compound as pale yellow oil, which was used in the subsequent step without further purification.NMR (1H, CDCI3): delta 7.3 (d, 2H), 6.8 (d, 2H), 5.1 (s, 1 H), 3.8 (s, 3H), 3.5 (s, 3H).
The synthetic route of 23786-14-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2006/108700; (2006); A1;,
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