Electric Literature of 35179-98-7, The chemical industry reduces the impact on the environment during synthesis 35179-98-7, name is Chloromethyl ethyl carbonate, I believe this compound will play a more active role in future production and life.
Example 40: 4-((R)-3-(Bis-ethoxycarbonyloxymethoxy-phosphoryl)-2-{[4-((S)-3- methoxy-pyrrolidin-l-yl)-6-phenyl-pyridine-2-carbonyl]-amino}-propionyl)-piperazine- 1-carboxylic acid butyl ester:A solution of intermediate 22.2 (100 mg) in abs. DMPU (0.3 mL) and NEt3 (68 muL) was stirred for 10 min at RT. Then, chloromethyl ethyl carbonate (650 mg, prepared as described in WO2004092189) and NaI (29 mg) were added at RT, and the reaction mixture was stirred overnight at 500C. The reaction mixture was diluted with H2O and the aq. phase extracted with toluene. The combined organic layers were dried over Na2SC^ and concentrated to dryness. CC (EA) gave 19 mg of the desired product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Chloromethyl ethyl carbonate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/125366; (2009); A1;,
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