Adding a certain compound to certain chemical reactions, such as: 431-47-0, name is Methyl 2,2,2-trifluoroacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 431-47-0, name: Methyl 2,2,2-trifluoroacetate
Example 7. Synthesis of a labeled compound of the present invention [a fluorescent labeling, 2′-deoxycytidine-5′-triphosphate derivative]; Mononucleotide (2′-deoxycytidine-5′-triphosphate) labeled with the compound [1] of the present invention was synthesized as follows according to the above-described synthesis route.(1) Synthesis of the partial linker (A); (i) Trifluoroacetylation (Tfa) (the first step); To 21 g of propagylamine, [the compound (51) in the above synthesis route], (manufactured by Tokyo Chemical Industry Co., Ltd.), methyl trifluoroacetate (MeOTfa) (54 g) and triethylamine (Et3N) (25 mL) were added, under ice-cooling, to be subjected to stirring at room temperature for 2 days. After completion of the reaction, purification was carried out under reduced pressure to give the compound (52), [the compound (52) in the above synthesis route], (56 g, yield; 98.1%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trifluoroacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Wako Pure Chemical Industries, Ltd.; EP2006289; (2008); A1;,
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