46064-79-3, name is Methyl 3-amino-4-bromobenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C8H8BrNO2
Benzoyl isothiocyanate (3.12 g, 19.1 mmol) was added to a stirred mixture ofmethyl 3-amino-4-bromobenzoate (4.0 g, 17.4 mmol) in acetone (40 ml) and the mixture was stirred at 60C for 6 hr. After being cooled to room temperature, the reaction mixture was evaporated under vacuum. The residue was purified by column chromatography on silica gel Isolute Flash Si; 50 g prepacked, eluted with EA/PE (0-30%) to give the title compound: LCMS (ESI) calc?d for C,6H,3BrN2O3S [M + H]: 393, 395 (1:1), found 393, 395 (1:1); ?H NMR (400 MHz, DMSO-d6): oe12.65 (s, 1H), 11.91 (s, 1H), 8.47 (d, J= 2.0 Hz, 1H), 8.02-8.00 (m, 2H), 7.92-7.91 (m, 1H), 7.81-7.80 (m, 1H), 7.78-7.69 (m, 1H), 7.58-7.54 (m, 2H), 3.88 (s, 3H).
The synthetic route of 46064-79-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BENNETT, Frank; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; GU, Xin; SCOTT, Jack D.; TANG, Haiqun; ZHAO, Zhiqiang; HUANG, Yuhua; HUNTER, David; YANG, Dexi; ZHANG, Zhibo; FU, Jianmin; BAI, Yunfeng; ZHENG, Zhixiang; ZHANG, Xu; YOUNG, Katherine; XIAO, Li; (580 pag.)WO2016/206101; (2016); A1;,
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