In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1236357-65-5 as follows. Product Details of 1236357-65-5
To degassed toluene (25 mL) was added palladium acetate (18 mg, 0.0825 mmol) and Xphos (79 mg, 0.165 mmol) and the mixture was degassed a further 30 minutes. To this reaction mixture was added methyl 1-(4-bromophenyl)cyclobutanecarboxylate (900 mg, 3.3 mmol) and cesium carbonate (3.2 g, 9.9 mmol) and this was degassed for a further 10 minutes. Beta-alanine ethyl ester (920 mg, 6.6 mmol) and diisopropylethyl amine (1.1 ml, 6.6 mmol) were added and this was brought to reflux and stirred overnight. The reaction was cooled to room temperature and poured onto water (100 ml). It was then extracted with ethyl acetate (2*100 ml), dried over magnesium sulfate, filtered, and evaporated to give methyl 1-(4-(3-ethoxy-3-oxopropylamino)phenyl)cyclobutanecarboxylate. Taken on crude to the next reaction. 1H NMR (400 MHz, CDCl3) 7.1 (d, 2H), 6.55 (d, 2H), 4.15 (m, 2H), 3.65 (s, 3H), 3.45 (m, 2H), 2.75 (m, 2H), 2.60 (t, 2H), 2.45 (m, 2H), 1.95 (m, 1H), 1.85 (m, 1H), 1.35 (m, 3H)
According to the analysis of related databases, 1236357-65-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; pfizer Inc; US2010/197591; (2010); A1;,
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