Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18830-44-9, name is Methyl 3,3,3-trifluoropropanoate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks
28.1. methyl 2-benzyl-4,4,4-trifluoro-3,3-dihydroxybutanoate To a solution of 675 mg (29.4 mmol) of sodium in 15 mL of anhydrous MeOH, under argon, are added dropwise 3.73 mL (29.4 mmol) of methyl 3,3,3-trifluoropropanoate. After stirring for 30 minutes at room temperature, 3.5 mL of benzyl bromide are added and the medium is heated for 12 hours at 70 C. The reaction mixture is then concentrated under reduced pressure. The residue obtained is taken up in 100 mL of EtOAc, washed with 50 mL of brine, dried over Na2SO4, filtered and concentrated under reduced pressure. After purification by chromatography on a column of silica gel, eluting with a cyclohexane/EtOAc mixture (85/15), 3.4 g of methyl 2-benzyl-4,4,4-trifluoro-3,3-dihydroxybutanoate are obtained in the form of an oil, which is used without further purification in the following step. Yield=37%.
The synthetic route of 18830-44-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
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