Related Products of 2901-13-5, These common heterocyclic compound, 2901-13-5, name is Ethyl 2-methyl-2-phenylpropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution – o’f 1 g- 2-methyl-2-phenyl-propionic acid ethyl ester in a mixture of 14 ml ‘sulfuric acid and 1 ml nitric acid was stirred at room temperature for 4 hours. The mixture was added to ice water and extracted with ethyl acetate. The organic layer wa’s washed with a satured aqueous solution of sodium hydrogen carbonate and dried over – anhydrous sodium sulfate. Filtration and concentration of the solvent under reduced pressure yielded a yellow solid;. The residue was purified- by, .flash chromatography on silica gel with a n-heptane/ dichloro-methane gradient. The fractions containing the product were combined and evaporated . to yield a yellow solid. Yield: 560 -mg.’- ‘ ‘ ‘M+H+. measured = ? ? ? ?1H-NMR’ (400 MHz, DMSO/TMS.)’1: ‘d = 8.69 (d, 1H) ; 8.5.3. (dd,’1H-); 8.10 ? (d, ‘1H) ; -”4 I 02 (q,–2H); 1.65 (s, 6H) ; ,1> 12 (t,
Statistics shows that Ethyl 2-methyl-2-phenylpropanoate is playing an increasingly important role. we look forward to future research findings about 2901-13-5.
Reference:
Patent; AVENTIS PHARMA S.A.; WO2006/10642; (2006); A1;,
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