Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6290-49-9, name is Methyl 2-methoxyacetate, A new synthetic method of this compound is introduced below., Product Details of 6290-49-9
Add 67.5g (1.25mol) to a 1000ml four-necked flaskSodium methoxide solid and 450ml of cyclohexane were heated to 50 C, and 52.0g (0.50mol) of methyl methoxyacetate was slowly added dropwise.Keep no more than 70 , about 1h dripping.Then keep the reaction at 80-90 for 16h. During this period, about 20ml of solvent was distilled off with water pump under reduced pressure every 3h, and 20ml of cyclohexane was added.The temperature was lowered to about 5 C, 6N hydrochloric acid was added to adjust pH = 6-7 (about 270ml), and then 200ml of water layer was added.The aqueous layer was extracted with cyclohexane (150 ml × 1), the organic layers were combined, washed with water (100 ml × 1), and decompressed under reduced pressure to obtain a brown liquid.Distillation under reduced pressure, collecting 114-115 C fraction (10 torr) to obtain intermediate III as a colorless transparent liquid, with a mass of 64.7 g, a yield of 73.7%, and a purity of 99.1%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Nanjing Jieyun Pharmaceutical Technology Co., Ltd.; Zhou He; Shu Kai; Fang Jing; Zhang Li; Song Xingchang; Yu Zenghui; Wu Xiaodong; Liu Haomin; (10 pag.)CN111004121; (2020); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics