Reference of 37746-78-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37746-78-4 name is (E)-Ethyl 4-bromobut-2-enoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4-Methoxybenzylamine (29.8 g, 217.2 mmol) was dissolved in ethanol (1 L), N,N-diisopropylethylamine (84.25 g, 651.6 mmol) was added, ethyl 4-bromocrotonate (75%, 122.96 g, 477.84 mmol) was slowly added, heated to 40C by using oil-bath, reacted for 16h. After completion of the reaction as measured by TLC (petroleum ether : ethyl acetate =5:1), the reaction solution was concentrated in vacuum, water (500 mL) was added, extracted with ethyl acetate (500 mL*2), the organic phases were combined and concentrated in vacuum, the crude product was purified by silica gel column chromatography (petroleum ether : ethyl acetate =10:1) to obtain the title compound (76 g, yield 96.8%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (E)-Ethyl 4-bromobut-2-enoate, and friends who are interested can also refer to it.
Reference:
Patent; Xuanzhu Pharma Co., Ltd.; WU, Frank; (77 pag.)EP3281942; (2018); A1;,
Ester – Wikipedia,
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