Reference of 57486-69-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57486-69-8, name is Methyl 2-(2-bromophenyl)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Synthesis of methyl 2-(2-(pyridin-4-yl)pIn a sealed degassed vial, methyl-2-(2-bromophenyl)acetate (550 mg, 2.4 mmol), 4-pyridine boronic acid (325 mg, 2.64 mmol), 2 M Na2C03 (4 mL), DME (8 mL), Pd(PPh3)4 (140 mg, 0.12 mmol) was combined. The vial was charged with argon and then placed in the microwave reactor, heating at 120 C for 20 minutes. Reaction was diluted with 10 mL of EtOAc and then washed with brine. The mixture was dried with MgS04 and then by reduced pressure. The title compound was obtained after purification by flash chromatography (100% hexanes to 50% EtOAc/hexanes): yellow oil (330 mg, 60%). MS ESI [M + H]+ 228.0, calcd for [Ci4H,3N02 + H]+ 228.1
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-(2-bromophenyl)acetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIVERSITY HEALTH NETWORK; LAUFER, Radoslaw; PAULS, Heinz W.; FEHER, Miklos; NG, Grace; LIU, Yong; EDWARDS, Louise G.; PATEL, Narendra Kumar B.; PAN, Guohua; MAK, Tak W.; WO2011/123937; (2011); A1;,
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