Introduction of a new synthetic route about 110661-91-1

Synthetic Route of 110661-91-1,Some common heterocyclic compound, 110661-91-1, name is tert-Butyl 4-bromobutanoate, molecular formula is C8H15BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthetic Route of 110661-91-1,Some common heterocyclic compound, 110661-91-1, name is tert-Butyl 4-bromobutanoate, molecular formula is C8H15BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

This was prepared as per 25e from 24 using t-butyl 4-bromobutanoate. Yield 21%. 1H NMR (300 MHz, CHLOROFORM-d) d7.18-7.33 (m, 3H), 7.09 (d,J= 6.78 Hz, 2H), 6.98 (br s, 1H), 6.87 (d,J= 8.29 Hz, 1H), 6.65-6.73 (m, 2H), 6.58-6.64 (m, 1H), 6.46 (dd,J= 2.17, 8.19 Hz, 1H), 6.33 (d,J= 2.07 Hz, 1H), 4.47 (dd,J= 8.01,14.98 Hz, 1H), 3.79 (s, 3H), 3.73 (s, 3H), 3.54-3.69 (m, 2H), 3.32-3.47 (m, 1H), 3.14 (t,J= 6.88 Hz, 2H), 3.07-3.32 (m, 2H), 2.76-2.99(m, 4H), 2.41-2.54 (m, 1H), 2.34 (t, J= 7.16 Hz, 2H), 1.90 (quin,J= 7.02 Hz, 2H), 1.46 (s, 9H).m/z588 (M+H)

The synthetic route of 110661-91-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Perrey, David A.; Decker, Ann M.; Li, Jun-Xu; Gilmour, Brian P.; Thomas, Brian F.; Harris, Danni L.; Runyon, Scott P.; Zhang, Yanan; Bioorganic and Medicinal Chemistry; vol. 23; 17; (2015); p. 5709 – 5724;,
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