Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 25542-62-5, name is Ethyl 6-bromohexanoate, A new synthetic method of this compound is introduced below., Safety of Ethyl 6-bromohexanoate
To a solution of triphenylphosphine (918 mg, 3.5 mmol) in MeCN (5 mL) was added 6-bromohexanoic acid ethyl ester (669 muL, 3.0 mmol). The mixture was refluxed for 7 h and concentrated. The residue was purified by silica gel column chromatography to give the target compound (1.14 g, 78%) as a white foam.1H NMR (500 MHz, CDCl3) delta: 7.89-7.85 (m, 6H), 7.81-7.78 (m, 3H), 7.72-7.68 (m, 6H), 4.07 (q, 2H, J = 7.3 Hz), 3.95-3.89 (m, 2H), 2.27 (t, 2H, J = 7.3 Hz), 1.76-1.72 (m, 2H), 1.66-1.58 (m, 4H), 1.22 (t, 3H, J = 7.3 Hz). FAB-MS m/z: 405 [M-Br]+.
The synthetic route of 25542-62-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Motoshima, Kazunori; Ishikawa, Minoru; Hashimoto, Yuichi; Sugita, Kazuyuki; Bioorganic and Medicinal Chemistry; vol. 19; 10; (2011); p. 3156 – 3172;,
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