73792-08-2, name is Methyl 4-amino-2-fluorobenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C8H8FNO2
Add in a 150 mL two-necked flask at room temperature 2-fluoro-4-aminobenzoic acid ester 2 (4.5 g, 26.6 mmol), acetone (2.99 g, 42.7 mmol), potassium cyanide (2.6 g, 40 mmol) and 46 mL of acetic acid, the mixture was heated to 75 C for 24 h, and the reaction was monitored by TLC ( petroleum ether: ethyl acetate = 20:3). After the reaction was completed, 20 mL of water was added to the reaction mixture, and ethyl acetate (40×3 mL) was evaporated.The residue was dissolved by adding a mixed solvent of 6 mL of ethanol and 5 mL of water. cooling crystals, filtering to give compound 21, 3.13 g, yellow solid, yield 50.2%.
The synthetic route of 73792-08-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Changsha Zeda Pharmaceutical Technology Co., Ltd.; Chen Yongheng; Xu Guangyu; Zhou Wenqiang; (23 pag.)CN108976171; (2018); A;,
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