40061-54-9, name is Ethyl 2-(2-chlorophenyl)acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C10H11ClO2
1. Take 100 ml of a dry single-mouth flask, and add 2-chloro-phenylacetic acid ethyl ester (1 g, 0.0054 mmol in 10 ml of methanol, then place the system in an ice bath and slowly add lithium aluminum hydride (0.41 g, 0.0108 mmol). ), continue to stir for 1 h after the additionAfter the reaction is completed, a small amount of water is added for quenching.Thereafter, methanol was removed under reduced pressure and extracted with 15 ml of ethyl acetate.After washing with saturated brine, the extract phase was collected and dried over anhydrous sodium sulfate overnight.After the end of drying, the solvent was removed under reduced pressure to give a colorless oil, Compound A,It was used directly in the next reaction without purification.
The synthetic route of 40061-54-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tianjin International Bio-pharmaceutical Joint Institute; Nankai University; Wang Ying; Cai Yan; Mao Yonghong; Guo Yu; Yu Zhenwu; Yang Yang; Zhao Peipei; He Wanli; (10 pag.)CN109897007; (2019); A;,
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