Related Products of 57267-03-5, A common heterocyclic compound, 57267-03-5, name is Ethyl 2,2,2-triethoxyacetate, molecular formula is C10H20O5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2,5-Diamino-benzene-1 ,4-dithiol hydrochloride (5.00 g; 20.39 mmol; 1.00 eq.) is suspended in anhydrous N,N-dimethylformamide (37 cm3) at 50 C. Anhydrous pyridine (3.39 g; 3.49 cm3 42.82 mmol; 2.10 eq.) is slowly added and the mixture stirred at 50 00 for 1 hour under a flow of nitrogen. The clear yellow solution obtained is transferred to a flask containing triethoxy-acetic acid ethyl ester (16.62 g; 75.45 mmol; 3.70 eq.) andyttrium(III) triflate (0.57 g; 1 .02 mmol; 0.05 eq.). Slow precipitation is observed. The mixture is stirred at 60 00 for 72 hours under nitrogen. Subsequently, the mixture is cooled to room temperature. The precipitate is isolated by filtration and washed copiously with methanol, yielding the product as a yellow powder (4.07 g, 59.3%).1H NMR (300 MHz, Chloroform-d) 6: 8.84 (5, 2H), 4.60 (q, 4h), 1.52 (t,6H).
The synthetic route of 57267-03-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; NANSON, Lana; PRON, Agnieszka; KROMPIEC, Michal; (147 pag.)WO2017/157782; (2017); A1;,
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