Related Products of 18469-52-8, A common heterocyclic compound, 18469-52-8, name is Methyl 4-(aminomethyl)benzoate, molecular formula is C9H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The compound 2,4-dichloro-6-nitro-quinazoline (0.115 g, 0.47 mmol) was weighed in a reaction flask,Isopropyl alcohol 4mL,Stir into suspension,Methyl p-aminomethylbenzoate (0.094 g, 0.56 mmol) and DIEA (0.106 g, 0.82 mmol) were added,Reaction at room temperature 2.5h.Stop stirring, add dichloromethane to make the reaction solution becomes clear, add silica gel,Concentration by column chromatography [petroleum ether / ethyl acetate = 10: 1 (v / v) / methylene chloride / ethyl acetate = 10: 1 (v / v)] gave 0.162 g of a yellow solid in a yield of 92.6%
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Chen Xiaoguang; Jin Jing; Zhu Lina; Zhang Chongjing; (85 pag.)CN102250075; (2016); B;,
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