Some common heterocyclic compound, 33993-24-7, name is Cyclopropanecarboxylic anhydride, molecular formula is C8H10O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 33993-24-7
Example 1; General Procedure for Demethylation/Acylation; Tertiary amine (0.1 mmol, 1.0 eq.) was dissolved in acetic anhydride (1 ml) and Pd(OAc)2 (0.01 mmol, 0.1 eq.) added. The reaction was heated at 80 C. for 15 hours, cooled to room temperature and passed through a plug of silica using CHCl3:MeOH:NH4OH 80:20:1 as eluent. The volatiles were removed in-vacuo, and the residue suspended in NaHCO3. The aqueous phase was extracted with CHCl3, and the combined organic extracts washed with 1M HCl and brine before being dried over magnesium sulphate, filtered and the volatiles removed in-vacuo to yield the acyl product.It will be understood by a person skilled in the art that the above description for Example 1 is provided for the general procedure. The examples shown below in Examples 1a-1j follow the general procedure outlined above, and shown in Scheme I from compound 3 to 7, but include the use of different sources of palladium and different amounts of Pd(OAc)2, where applicable, and the use of different solvents, as indicated in the table below.; Example 2; Reactivity of a Series of Anhydrides; The reactivity of a series of anhydrides was explored following the general procedure outlined in Example 1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 33993-24-7, its application will become more common.
Reference:
Patent; Brock University; US2009/5565; (2009); A1;,
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