Synthetic Route of 39149-80-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39149-80-9 name is tert-Butyl 2-bromopropanoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of tert-butyl [(li?,2No.)-l-(hydroxymethyl)-2,3-dihydro-lH-inden-2- yl]carbamate (Intermediate 6: 2.63 g, 10.0 mmol) in DCM (30 mL) was added tert-butyl- (2R/S)-bwmo propionate (2.6 g, 12.5 mmol), tetrabutylammonium hydrogen sulphate (850 mg, 2.5 mmol) and sodium hydroxide (9.6 mL, 50% w/v aqueous, 120.0 mmol) and the reaction stirred at ambient temperature for 3 h. Water (50 mL) was added and the mixture extracted with DCM (2 x 50 mL). The organic extracts were washed with water (25 mL), brine (25 mL), dried (MgSO4) and the volatiles removed under reduced pressure. The residue was purified by flash chromatography with (SiO2, wo-hexane:EtOAc, 3:1) gave the title compound (2.5 g, 64%) as an oil. 1H NMR delta (CDCl3): 1.42(m, 21Eta), 2.78(ddd, IH), 3.23(m, IH), 3.35(m, IH), 3.57(m, IH), 4.85(m, 2H), 4.14(m, IH), 4.9(m, IH), 7.17(m, 3H), 7.37(m, IH); MS m/z 414 (M+Na).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 2-bromopropanoate, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/82400; (2006); A1;,
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