Reference of 57625-74-8,Some common heterocyclic compound, 57625-74-8, name is Methyl 2-methyl-2-phenylpropanoate, molecular formula is C11H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step C. To a suspension ofAlCl3 (500.0 mg, 3.75 mmol) inCH2Cl2 at-10 C was added dropwise oxalyl chloride (476.0 mg, 3.75 mmol) inCH2C12. The mixture was stirred at this temperature for 30 min. Then a solution of 2-methyl-2- phenyl-propionic acid methyl ester (178.0 mg, 1.0 mmol) inCH2C12 was added. The resulted mixture was stirred at-10 C for 1 hr and rt overnight. The mixture was filtered through a pad of celite, the solvent and excess oxalyl chloride was removed under reduced pressure. The residue was dissolved in chlorobenzene and refluxed for 4 hr. Solvent was removed and the residue was dried to give2- (4- chlorocarbonyl-phenyl) -2-methyl-propionic acid methyl ester.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-methyl-2-phenylpropanoate, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99276; (2003); A1;,
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