Related Products of 6482-34-4, A common heterocyclic compound, 6482-34-4, name is Diisopropyl carbonate, molecular formula is C7H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 5 Synthesis of methyl 2,2,3,3-tetrafluoropropyl carbonate (the compound of the formula [I] where R1 =H and R2 =1,1,2,2-tetrafluoroethyl) In a flask (500-ml volume) equipped with 10 distillation columns, 2,2,3,3-tetrafluoropropanol (100 g, 0.76 mol), dimethyl carbonate (205 g, 2.3 mol) and a 28% sodium methoxide/methanol solution (1.4 g) were charged. The flask was heated to 120 C. to allow the starting materials to react for 10 hours while removing the methanol from the distillation columns by evaporation. After allowing the mixture to cool to room temperature, an aqueous solution of ammonium chloride was added to the mixture and the mixture was shaken to remove the sodium methoxide. The organic layer was washed with water, dried and distilled to give methyl 2,2,3,3-tetrafluoropropyl carbonate as a colorless liquid (70 g, yield 49%). The chemical structure of the produced compound was determined based on the IR and NMR absorbance spectra shown in FIG. 9 and FIG. 10 respectively and the mass spectrometry spectrum (M/e=190). The absorbance peaks of IR and NMR are shown below. IR (neat): 2964 (C–H), 1764 (C=O), 1446, 1396, 1277, 1204, 1106, 994, 834, 787, 662, 580, 534 cm -1 NMR (CDCl3 soln., delta ppm): 3.86 (s, 3H, OCH3), 4.53 (t, 2H, J=12.5 Hz, OCH2 CF2 CF2 H), 5.90 (tt, 1H, J=53.1 Hz, H=4.3 Hz, OCH2 CF2 CF2 H)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Mitsui Petrochemical Industries, Ltd.; Sony Corporation; US5659062; (1997); A;,
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