Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6290-49-9, name is Methyl 2-methoxyacetate, A new synthetic method of this compound is introduced below., COA of Formula: C4H8O3
Intermediate 51 l-(5-Fruoropyridin-2-yl)-2-methoxyethanoneTo a solution of 2-bromo-5-fluoropyridine (15.0 g, 85.23 mmol) in methyl t-butyl ether (250 ml) at -78 0C was added tert-butyllithium (60.2 ml, 102.28 mmol) with caution.After the addition of the organolithium was completed, the resulting black solution was stirred at-78 0C for 15 minutes whereupon methyl 2-methoxyacetate (8.43 ml, 85.23 mmol) in 10 mlMTBE was added to the solution. The mixture was stirred for 3 hours at -78 0C whereupon saturated NH4Cl was added in order to quench the reaction.The mixture was partitioned between EtOAc and brine and the organic extract was dried and evaporated under reduced pressure. Purification by column chromatography (20% ->40%EtOAc/hexanes) gave the titled compound as a yellowish solid 6.19 g (43% yield). LCMS: 170[M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/132502; (2008); A1;,
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