Reference of 13671-00-6, A common heterocyclic compound, 13671-00-6, name is Methyl 2,6-difluorobenzoate, molecular formula is C8H6F2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of compound 1 (21.0 g, 122.0 mmol) in concentrated sulfuric acid (50 mL) was added fuming nitric acid (8 mL) dropwise at 0 C. After the reaction mixture was stirred at 0 C for 1 h, it was poured into ice-water. The precipitate was collected by filtration and rinsed with water to give 2 (26.0 g, 98%) as a white solid, mp 58-60 C. 1H NMR (CDCl3): delta 8.25-8.22 (m, 1H), 7.15-7.11 (m, 1H), 4.01 (s, 3H).
The synthetic route of 13671-00-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Zheng, Qi-Huang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 4; (2013); p. 1017 – 1021;,
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